The Expansion of Higher Vocational Education meets the needs of the industrial policy oriented towards talents and focuses on the technical and skilled talents in the key areas of Regional Economy. Based on the current situation, this paper makes an empirical analysis and research on enrollment and majors. According to the characteristics of the sources of students, it is proposed to strengthen the government's overall role, connect with the pillar industries and optimize the setting of the majors. At the same time, the Industrial College is suggested to be established by cooperating with the Vocational Education Group of Zhuhai to implement the modern apprenticeship system to improve the participation of enterprises, which will promote the coordination of the Expansion of Higher Vocational Education and the development of regional industries.