Under the background of creating five “golden courses” in universities across the country, the construction of virtual simulation experimental teaching projects has gradually become a necessary part of talent training and discipline construction in the universities. The organic chemistry virtual simulation experiment is an important means of organic chemistry experiment teaching, which can complete the experiment that are difficult to carry out in real experiments, and is a good supplement to experiment teaching. Then this paper analyzes the advantages and disadvantages of organic chemistry virtual simulation experiment and organic chemistry real experiment, and explored how to design the virtual simulation experiment of organic chemistry, follows the “Golden Course” standards.