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| Study on the Anti-tumor and Immune-enhancing Activities of Polysaccharides from Sargassum Fusiforme |
| ZHANG Xiao-wei，LI Lu，LIU Yi-han，ZENG Zi-qi，ZHU Jia-le，XU Hong-yu，ZHANG Yuan-xin，GE Ya-kun*
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| College of Biology and Food Engineering, Jilin University of Chemical Technology, Jilin 132022 |
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Abstract Sargassum Fusiforme polysaccharides (SFPS) are a natural bioactive product with broad biological activities and low toxicity. In this study, mouse ID8 ovarian cancer cells and mouse macrophage RAW264.7 cells were selected as the research subjects. Methods such as MTT assay, qPCR, and flow cytometry were employed to evaluate the direct antitumor activity of SFPS and its ability to polarize macrophages. The results showed that SFPS did not exhibit a significant direct inhibitory effect on the proliferation of ID8 cells. However, it significantly upregulated the mRNA levels of M1-type macrophage polarization markers. The polarized macrophages demonstrated a relatively slightly superior ability to induce early apoptosis in ID8 cells.
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Published: 22 March 2026
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