vIn this study, the sorption behavior of oxytetracycline and Ciprofloxacin on CPE, Pe and polyvinyl chloride was studied, the results showed that the adsorption capacity of microplastics to antibiotics was affected by the properties of microplastics, the kinds of antibiotics and the background solution, and the effect was very significant. The adsorption of oxytetracycline and oxytetracycline on micro-plastics was as follows: CPE (polyethylene) polyvinyl chloride (PE) PE, the adsorption of oxytetracycline in pure water was not significantly different from that in fresh water; The adsorption capacity of CPE TO CIPROFLOXACIN in pure water was stronger than that in fresh water.