In the new era, innovation and entrepreneurship education is a process of people-oriented personnel training. Through continuous exploration of educational mechanisms, the concept of innovation and entrepreneurship is integrated into the process of education. By analyzing the internal and external factors of innovation and entrepreneurship education, this article uses the external driving forces such as social reform, resource investment, incubation of the production, education and research and its guarantee in the later process to cultivate students' entrepreneurial personality and sense of innovation. The research focuses on the improvement of the students' comprehensive ability and practical ability, on increasing their social competitiveness, which provides strong support for cultivating innovative entrepreneurship talents.