By integrating spirit of craftsmanship into the cultivation process of aircraft electro-mechanic equipment maintenance talents, this paper aims to introduce the process of setting goals of cultivating personnel according to the demand of employment after the discussion with corporate and industrial experts. The cultivation of craftsmanship permeates into the whole teaching process through enhancing the foundation and appreciating practice teaching. In the end, by combining internal and external practice and introducing enterprise culture, the students' professional qualities improve through promotion of the teachers' level, reform of teaching content, teaching methods and assessment methods.