Audio-Visual-Oral English is one of core courses for English majors, which plays a significant role in the cultivation of interdisciplinary English talents. With the adjustment of talent training mode under the background of the new liberal arts, the audio-visual-oral English course is required to be defined afresh and change the traditional teaching method which attaches importance to language skill training and neglects the infiltration of professional connotation. Teachers should integrate the basic knowledge of various subjects into the curriculum content in the flipped classroom, which enables students to possess more profound English knowledge and cross-subject knowledge while developing their English language skills so that students can grow into interdisciplinary English talents who can adapt to the development of the new era.