In order to accelerate the construction of the safety professional talent team, solve the problem of insufficient number of chemical and safety-related professionals, it is necessary to build a "big chemical" safety professional training base construction model. The model gives full play to the advantages of resource integration of "school, government and enterprise", and design training modules, training content and training methods. The overall training mode has the characteristics of full spatial coverage, diversified modules (combination of theory, practice and VR simulation) and process dynamic continuity. The research results provide ideas and references for the follow-up training practice, and effectively assist the training of safety professionals.