To promote the students’ engineering practice and innovation ability and solve the problems such as limited comprehensive practice hours, training without distinction of levels, incomplete system of Comprehensive Practice of Analog Electronic Technology, ECG Signal Acquisition System teaching is taken as an example to analyze the “Online + Offline” teaching mode. Meanwhile, LiChuang EDA are introduced in the hierarchical, engineering, innovative, informational, modular and diversified comprehensive experimental process, and the result of comprehensive design is verified. Practice shows that the introduction of EDA virtual platform into practice teaching can assist online teaching and ensure the effective implementation of offline hierarchical, engineering and innovative teaching mode.