Based on the background of engineering education accreditation and the "Internet plus", this paper explores the mixed teaching model of "Solid Waste Treatment and Disposal" course, and the "student-centered" transformation is realized. From the aspects of building curriculum resources, operating mechanism of mixed teaching model, evaluation of learning effect, teaching content, teaching ways and methods and etc., the reform and innovation of online and offline mixed teaching model was put forward and the teaching quality and teachers' teaching ability and level was improved.