Chemical big data will bring new industry development direction and economic growth for the development and management of chemical industry. It is of great practical significance to establish big data-related majors in universities with chemical characteristics to cultivate inter-disciplinary talents facing the information era so as to support the development of modern chemical industry. This paper demonstrates the necessity of the construction of data science and big data technology majors in universities with chemical characteristics, analyzes the current situation of data science and big data majors in chemical universities, proposes the talent training strategy of "clarifying the connotation, promoting layer by layer, optimizing teachers, enabling applications, and monitoring quality" for data science and big data technology majors.