The strategies of integrating theory of Marxism Sinicization into ideological and political education in colleges and universities are explored by combining theory and practice in this paper, and the results of the exploration shows that Marxism Sinicization is helpful in cultivating the students' truth-seeking and pragmatic mentality and good identification ability. The research also shows that using the Internet to carry out ideological and political education, assisting students to establish scientific thinking, creating a harmonious and friendly campus environment, and building an excellent team of teachers, can help to spread the theory of Marxism in China better.