Full integration of professional education and innovation and entrepreneurship education is an important way to transform local application-oriented undergraduate colleges. At present, the integration of professional education and innovation and entrepreneurship education has the characteristics of one-sided, fragmented and superficial, which is not conducive to the achievement of the training goals of local. The integration of the entire value chain of professional education and innovation and entrepreneurship education should adhere to the values, codes of conduct and methods, and realize the integration and penetration of the entire teaching link and the entire teaching space of professional education and innovation and entrepreneurship education.