In view of the shortcomings of the application of modern information technology in the education of major engineering colleges and universities in China, this paper puts forward the practical methods of "multi-integration" curriculum system in higher education. Combining with the idea of outcome-oriented education, MOOC is introduced, and the traditional teaching content is divided into three levels: basic theory, knowledge extension and practical application. The teaching methods and means at each level are given, and the self-optimizing mode of curriculum system is put forward. At the same time, the general implementation steps of the "multi-integration" are given, which can be used for reference in the informationization reform of higher education and the construction of course of high quality.