The construction of environmental laboratory management system in colleges and universities isrealized through the construction of risk hierarchical management and control and hidden danger screening andtreatment by referring to the application experience of the dual prevention system in other industries.On thisbasis,the four-stage analysis of risk hierarchical management and control is carried out to determine the risklist and its control measures,and the corresponding security risk map is drawn to form the operation mechanismof risk hierarchical management and control.In addition,according to the results of the second stage of hiddendanger investigation and management,the information of risk points and danger sources is supplemented andimproved,so as to promote the in-depth defense of laboratory management,moving forward of the entrance,andimprove the level of laboratory management.Thus,the dual prevention system is used to promote themanagement of environmental laboratories in colleges and universities and to arouse the administrator attentionso as to improve the management level of environmental laboratories,prevent safety accidents effectively,whichis supposed to provide reference for the prevention of accidents in college laboratories.