This paper introduces the general idea, teaching cases and practical achievements of the training of interdisciplinary Japanese talents under the guidance of the Content and Language Integrated Learning(CLIL) model, and clarifies the important role played by the "three orientations", namely, problem orientation, goal orientation and career orientation, in improving college students' ability to use Japanese in multiple situations and enhancing their "self-confidence" and "sense of gain". At the end of this paper, the author discusses the practical significance of the CLIL model for cultivating high-quality Japanese talents in the new era.