Journal of Jilin Institute of Chemical Technology, 2021, 38(9): 112-116    doi: 10.16039/j.cnki.cn22-1249.2021.09.021
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Research on Gene Regulatory Network Based on Correlation Analysis and Principal Component Analysis
DONG Yi,LU Yunlong*
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Abstract  

In order to construct a gene regulatory network model, a method combining correlation analysis and principal component analysis is proposed. Use Pearson's correlation coefficient for correlation analysis to construct an initial gene regulatory network. Then use the principal component analysis method to establish the trimming principle, so as to obtain a new gene regulatory network.  Using the expression data of 10 genes of Escherichia coli (Ecoli1) in Dream3 for testing, the results show that referring to the benchmark network under the gold standard, the gene regulation network obtained by the proposed method has high accuracy.

Key words gene regulatory network      principal component analysis      correlation analysis      Pearson correlation coefficient      
Published: 25 September 2021
:  TP391  
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DONG Yi
LU Yunlong
Cite this article:   
DONG Yi,LU Yunlong. Research on Gene Regulatory Network Based on Correlation Analysis and Principal Component Analysis [J]. Journal of Jilin Institute of Chemical Technology, 2021, 38(9): 112-116.
URL:  
https://xuebao.jlict.edu.cn/EN/10.16039/j.cnki.cn22-1249.2021.09.021     OR     https://xuebao.jlict.edu.cn/EN/Y2021/V38/I9/112