卟啉及其卟啉基聚合物光动力学的比较研究

doi:10.16039/j.cnki.cn22-1249.2020.05.010

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摘要

光动力疗法（Photodynamic Therapy，PDT）是不同于手术、放疗、化疗和免疫治疗的一种崭新疗法，对血管增生性病变组织的选择性治疗具有很好的疗效。本文比较了三种卟啉及卟啉基聚合物的生物相容性和光动力学疗效。MTT测试结果显示，在非光照下Por、Por-PNIPAM、Por-PNIPAM-b-POEGMA对小鼠成纤维细胞L929和人宫颈癌细胞HeLa的毒性均较低；而在红光照射下，Por、Por-PNIPAM、Por-PNIPAM-b-POEGMA对L929细胞毒性较低，但对HeLa细胞毒性较高。

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	刘长玲
	杜昌明
	肖翠
	宋岩

关键词: 光动力疗法卟啉细胞毒性

Abstract:

Photodynamic Therapy (PDT) is a new treatment that is different from surgery, radiotherapy, chemotherapy and immunotherapy. It has a good effect on the selective treatment of angiogenic tissues. This article compared the biocompatibility and photodynamic efficacy of three porphyrins and porphyrin-based polymers. MTT test results showed that Por, Por-PNIPAM, and Por-PNIPAM-b-POEGMA were less toxic to mouse fibroblasts L929 and human cervical cancer cells HeLa under non-light; while Por, Por-PNIPAM and Por-PNIPAM-b-POEGMA are less toxic to L929 cells, but higher to HeLa cells.

Key words: Photodynamic Therapy porphyrin Cytotoxicity

出版日期: 2020-05-25 发布日期: 2020-05-25 整期出版日期: 2020-05-25

TQ050.4

引用本文:

刘长玲, 杜昌明, 肖翠, 宋岩.

卟啉及其卟啉基聚合物光动力学的比较研究 [J]. 吉林化工学院学报, 2020, 37(5): 42-45.
LIU Changling, Du Changming, Xiao Cui, SONG Yan. Comparative Study on Photodynamics of Porphyrins and Their Porphyrin-Based Polymers . Journal of Jilin Institute of Chemical Technology, 2020, 37(5): 42-45.

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https://xuebao.jlict.edu.cn/CN/10.16039/j.cnki.cn22-1249.2020.05.010 或 https://xuebao.jlict.edu.cn/CN/Y2020/V37/I5/42

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