In this paper, we explore the teaching method of comprehensive experiment of communication principle. According to the differences of students and the characteristics of the comprehensive experiment, a layered project-driven comprehensive experimental project was designed. In order to better implement the experimental project, the flipped classroom teaching method is introduced into the comprehensive experiment of communication principle. The practice shows that the project-driven teaching method and the flipped classroom are very suitable for comprehensive experimental teaching. With the change of professional Talent Cultivation Plan, experimental time is compressed. To ensure the effect of experimental classroom teaching, the Small Primary Online Course (SPOC) teaching model was applied to comprehensive experiments. In order to supervise and urge students to study online, a performance evaluation system was designed to evaluate students' online and offline learning results.