Based on the important role of distribution center location planning in the operation of the third-party logistics enterprises, this paper analyzes the problems of distribution center in S city of Y logistics company by taking the distribution center in S city of Y logistics company as an example, studies the location of distribution center by using analytic hierarchy process, establishes the hierarchical structure model and judgment matrix through qualitative analysis and quantitative analysis, so as to determine the optimal location. And then this paper provides reasonable suggestions for the location of the distribution center of the third-party logistics enterprises in order to improve the operation efficiency and reduce the distribution cost of the enterprise.