The connotation and correlation of teaching interaction and learning engagement is explained in this paper. Taking the public course College Computer as an example, the influence of teacher-student interaction, student-student interaction, student-content interaction and student-platform interaction on college students' learning involvement in online classroom was investigated by using questionnaire and data analysis. On the basis of the results of data analysis, this paper provides enlightenment for enriching the interactive form of teaching, promoting learning engagement and further improving the quality of online classroom teaching.