The teaching reform of Applied Mathematical Statistics is discussed in this paper by analyzing teaching content, teaching methodologies, practical training and course resource construction, aiming at the problems in the teaching process and the requirements of the educational objectives．On the premise of consolidating the theory, we concentrate on the statistical application and conduct case study to stimulate students' passion for learning. This education reform will help graduate students enhance their awareness of practice and application as well as improve their abilities in operating software and analyzing data, so as to meet the research requirements of statistical application.