Engineering Thermodynamics and Heat Transfer is an important basic course in engineering disciplines such as energy, power. It is related to heat transfer and system analysis, and it has the characteristics of profound theory, strong practicality and complex calculation. This paper takes this course as the research object to explore the reform and innovative exploration of the teaching methods for Engineering Thermodynamics and Heat Transfer under a multi-disciplinary model. It emphasizes the students' engagement and practical experience, aiming to provide useful ideas and methods for the teaching reform of this course through the combination of a variety of teaching methods.