Based on the 4I principle of network integrated marketing, this paper studies the teaching of information literacy and provides theoretical basis and practical thinking for the information literacy curriculum and teaching design of university libraries. The value of 4I principle for information literacy teaching is reflected in strengthening teaching guarantee ability, promoting teacher-student interaction and improving course quality. The four principles of interesting, interests, interaction and individuality which are emphasized by 4I principle can be applied in teaching content, teaching purpose, teaching method and teaching design respectively. The application of 4I principle in information literacy teaching is a kind of student-demand-oriented teaching exploration, which attracts students to actively participate in the teaching process through novel teaching mode so as to improve the teaching effect.