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Study on
Preparation Technology and Activity in Vitro of Shenmei Wuwei Granules
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XU Jinghui, WANG Xiaolin1*, ZHONG
Fangli ,CHEN Hao, LIU Junyu
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Abstract The extraction and preparation of total saponins from Shenmei Wuwei granules were studied, and the activity in vitro of the extract was explored.Single factor and orthogonal experiment were applied to optimize the extraction technology of total saponins from Shenmei Wuwei materials and the preparation technology of granules.The content of total saponins in extract was determined by ultraviolet spectrophotometry, and the activity in vitro of the total saponins extracted from Shenmei Wuwei granules was discovered by α-glucosidase inhibition rate and DPPH free radical scavenging. The optimum extraction technology was obtained as follows: extraction solvent, temperature, extraction time, material-to-liquid ratio and extract times were 70% ethanol solution, 80 ℃, 1:10 (g/mL), 2.5 h and 2 times respectively which offered the extraction rate of total saponins from Shenmei Wuwei materials to 7.36 mg/g. The preparation process of Shenmei Wuwei granules was as follows: the mass ratio of extract powder to diluent was 1:1 (g:g), the mass ratio of lactose to dextrin in diluent was 2:1 (g:g), sucralose was used as the flavor correcting agent, and the wetting agent was 85%. ethanol solution. Activity test results showed that the total saponins of Shenmei Wuwei had good hypoglycemic and antioxidant activities in vitro. Shenmei Wuwei granules provides basis for its further research and development in health food field.
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Published: 25 January 2024
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