In the era of Big Data, with the promotion of the "Internet + chemical industry" model, the O2O supply chain of chemical products has become the mainstream of the times. Due to the problems of some chemical enterprises in O2O operation mode, information sharing and logistics management, the supply chain collaborative management operation mode of enterprises is blocked. Big Data is used to achieve online and offline integration in this research, which has improved logistics management capabilities, and achieved information sharing by collaborating with blockchain technology, thus promoted the coordinated development of various enterprises in the supply chain and helped the construction planning of the Chemical product O2O supply chain.