Computer laboratory is an important place for school teaching. Most of the professional teaching practice activities in the school are basically carried out in the computer laboratory. Maintaining the computer equipment in the laboratory plays a vital role in improving the service life of the computer. However, many schools do not pay attention to the maintenance and management of the computer at present, which leads to the unreasonable use of the laboratory. Based on this situation, this paper discusses the management and maintenance of university computer laboratory, so as to better improve the maintenance and management level of computer laboratory.