In the teaching system, the cultivation of the "discipline core literacy" of chemistry has been gradually concerned. Understanding the connotation of discipline "core literacy", analyzing the essence and rules of knowledge is the basic of cultivating core literacy, tracing the source of knowledge is the condition of cultivating students' core literacy. Moreover, the effective way to cultivate students' core quality is to integrate the framework, and the way to acquire knowledge is the key to cultivate students' core literacy. Attaching importance to modern teaching technology is the innovation and good means for students to acquire knowledge. The strategy of using modern education technology can help comprehensively to improve the college students’ core quality.