In order to meet the development needs of building a characteristic and high-level application-oriented university, we analyzed the connotation and characteristics of STS education and put forward the reform and practice strategies of Inorganic Chemistry course teaching based on STS education from the aspects of course teaching content, teaching methods and modes, as well as practical teaching, etc. The analytical framework of STS implementation in practical teaching proved that STS education is very important for course construction and the cultivation of students' science literacy and comprehensive application ability. These studies will provide reference for science course teaching in engineering colleges for the promotion of STS education and achieve the goal of personnel training.