Under the background of the rapid development of the electronic industry, the role of single-chip microcomputer course is becoming more and more important for students. However, students are not easy to learn and have no interest in learning the course. They regard themselves as the audience, which leads to the course content that students master can not keep up with the pace of the development of the times.This paper puts forward the teaching reform ideas of online and offline hybrid large class flipped, combines online autonomous learning with the offline flip teaching, and the students learn the basic theory independently through the network platform, and the knowledge extension part is carried out in the multimedia classroom in the form of flip classroom. To make students targeted learning, improve the enthusiasm of learning micro-computer knowledge, through the results of teachers and students to prove that the teaching reform has achieved certain results.