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| Metabolomic Mechanism of Longdan Xiegan Decoction in the Treatment of Chronic Oxidative Liver Injury |
| Zhang Ranran1, Zhang Yan2*, Yang Xiudong 1*
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| 1.School of Chemical and Pharmaceutical Engineering, Jilin University of Chemical Technology, Jilin City 132000，China;2.College of Medicine, Jiaxing University, Jiaxing 314001,China |
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Abstract D-galactose was used to establish a model of chronic oxidative liver injury in rats, and to study the metabolomics mechanism of Longdan Xiegan Decoction（LXD） in treating chronic oxidative liver injury in rats. After 6 weeks of continuous modelling and drug administration, urine and faecal samples were collected. The relevant markers in urine and faeces were screened and identified based on GC-MS technology coupled with metabolomics methods. The results showed that the treatment of chronic oxidative liver injury in rats by LXD was associated with the effects of trans-aconitic acid, sebacic acid, lauric acid, ketoglutaric acid, nicotinic acid, indoleglycolide, fenugreek acid, nicotinamide, fatty acids, malic acid, L-aspartic acid, uridine, quinolenic acid, citric acid, O-acetylserine, stearic acid, isocitric acid, chondroitinic acid, phenylacetic acid, alanine, 3-phosphoglycerol, arginine, 6- Glucose phosphate, 2hydrouracil, 2-hydroxybutyric acid, hydroxylamine, 2-hydroxyglycolic acid, and 27 biomarkers and pathways related to the TCA cycle, glycerol catabolism, and fatty acid catabolism.
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Published: 20 December 2025
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