Abstract: Sargassum Fusiforme polysaccharides (SFPS) are a natural bioactive product with broad biological activities and low toxicity. In this study, mouse ID8 ovarian cancer cells and mouse macrophage RAW264.7 cells were selected as the research subjects. Methods such as MTT assay, qPCR, and flow cytometry were employed to evaluate the direct antitumor activity of SFPS and its ability to polarize macrophages. The results showed that SFPS did not exhibit a significant direct inhibitory effect on the proliferation of ID8 cells. However, it significantly upregulated the mRNA levels of M1-type macrophage polarization markers. The polarized macrophages demonstrated a relatively slightly superior ability to induce early apoptosis in ID8 cells.
张小薇, 李璐, 刘奕含, 曾子棋, 朱家乐, 徐洪宇, 张元新, 葛雅琨. 羊栖菜多糖抗肿瘤及增强免疫活性研究[J]. 吉林化工学院学报, 2025, 42(9): 7-10.
ZHANG Xiao-wei, LI Lu, LIU Yi-han, ZENG Zi-qi, ZHU Jia-le, XU Hong-yu, ZHANG Yuan-xin, GE Ya-kun. Study on the Anti-tumor and Immune-enhancing Activities of Polysaccharides from Sargassum Fusiforme. Journal of Jilin Institute of Chemical Technology, 2025, 42(9): 7-10.
