The concept of "one health" is an idea aimed at the healthy and unified development of people, animals and the environment. Combining the concept with research and learning helps to cultivate the humanistic feelings and life education of primary and secondary school students. Research-based learning is an off-campus research experience to enhance students' experience of society and life. The long-term sustainable and stable development of primary and secondary school research projects can promote the overall development of students.  This paper intends to discuss the organization and implementation of 4 research projects, and explored the problems and improvement measures, which is expected to provide a reference for integration of quality resources, laboratory management and education development in medical laboratories of universities.