In view of the importance of innovation and practical ability in the cultivation of college students, we give specific teaching reform methods of data mining course of charming mathematics. Firstly, we put forward the key problems to be solved in the curriculum teaching reform. Secondly, we give seven methods of innovative curriculum construction. Finally, we give a teaching design case based on BOPPPS teaching mode. Through the "student-centered" curriculum reform, students' comprehensive ability and innovation ability to solve complex problems have been significantly improved. And their practical ability of innovation and entrepreneurship has been further strengthened.