The cultivation of comprehensive qualities for college students not only plays an important role in personal development, but also promotes sustainable social development. At present, there is a disconnect between theory and practice in the cultivation of comprehensive qualities for college students, a lack of synergy in comprehensive quality education, and the inability to accurately implement comprehensive quality education. It has higher requirements for comprehensive quality in the new era. It has studied the connotation of college students' comprehensive quality by the perspective of development, it has proposed a holistic simulation model and collaborative development model for the comprehensive quality of college students, it has improved the comprehensive quality training system for college students, established, comprehensively explained the collaborative cultivation model for college students' comprehensive quality in the new era. It is an effective way that cultivates talents with high comprehensive quality to enhance the country's economic, cultural, technological, and innovation capabilities.