The scientific research and teaching work in colleges and universities are inseparable from the laboratory. Laboratory safety is one of the basic links of a safe campus, and laboratory safety access is the first pass of laboratory safety management. Taking Jilin Institute of Chemical Technology as an example, this paper studies the construction of safety access system of chemical laboratories, which helps to improve the safety management level of laboratory, effectively reduce the safety risk of laboratory, and ensure the teachers' and students' lives and property, and it also provides reference for the safety management of chemical laboratories in colleges and universities.