This article discussed with 2, 2 '- methylene double (4 - methyl - 6 - tertiary butyl phenol) referred to as the antioxidants, （antioxidant 2246) reaction, propionyl chloride as raw materials, triethylamine as the bound acid agent, using dichloromethane as solvent, the direct synthesis of 2 - (2 - hydroxy - 3 - tert-butyl - 5 - methyl benzyl) - 4 - methyl - 6 - tert-butyl phenyl propionate (hereinafter referred to as antioxidant 3426) method.The effects of molar ratio n(antioxidant 2246):n(propionyl chloride), reaction time and reaction temperature on the yield were studied.The synthesis method is green and the solvent can be recycled, in line with the concept of green chemistry.