In the context of the new normal economy, the School of economics and management relies on the characteristics of the “big chemical industry” of schools to integrate the superior resources of schools and local enterprises. From the signing of the practice base, the construction of the laboratory, the oriented cultivation of talents, the introduction of enterprise mentors into the classroom, the construction of double-qualified teachers and other aspects, this paper explores a multi-path collaborative cultivation mode. It has effectively improved the quality of talent cultivation in local undergraduate colleges and universities, and provided a strong talent guarantee for the development of local economy by feeding enterprises with a large number of high-quality talents.