Objective：In order to exploring new ways of accurately applying models for clinical practice. Method: This paper selects orthogonal and uniform experimental designs which are commonly used in medicine to establish different models, on the basis of goodness of fit test and difference examination to judge the model. Result: Different experimental designs for the same purpose have different models. Conclusion:The same experimental purpose and experimental design,  according to the goodness of fit test and difference examination, the best model can be explored by combining professional knowledge and preliminary experiment.