Effect on the dissolution rate and interactions between drug and excipients in the solid dispersions of gemfibrozil prepared by three methods. The dissolution rates of the drug in the solid dispersions have been increased significantly. The dissolution rates of the pure drug and the solid dispersions prepared by the solvent, freeze-drying and grinding method are 37.37%, 98.13%, 97.37% and 86.73% respectively during 2 hours. The characteristics of interactions between drug and carrier were analyzed by powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Gemfibrozil solid dispersion prepared by solvent method displays the most optimal properties.