Metabolomic Mechanism of Longdan Xiegan Decoction in the Treatment of Chronic Oxidative Liver Injury
Zhang Ranran1, Zhang Yan2*, Yang Xiudong 1*
1.School of Chemical and Pharmaceutical Engineering, Jilin University of Chemical Technology, Jilin City 132000，China;2.College of Medicine, Jiaxing University, Jiaxing 314001,China
Abstract: D-galactose was used to establish a model of chronic oxidative liver injury in rats, and to study the metabolomics mechanism of Longdan Xiegan Decoction（LXD） in treating chronic oxidative liver injury in rats. After 6 weeks of continuous modelling and drug administration, urine and faecal samples were collected. The relevant markers in urine and faeces were screened and identified based on GC-MS technology coupled with metabolomics methods. The results showed that the treatment of chronic oxidative liver injury in rats by LXD was associated with the effects of trans-aconitic acid, sebacic acid, lauric acid, ketoglutaric acid, nicotinic acid, indoleglycolide, fenugreek acid, nicotinamide, fatty acids, malic acid, L-aspartic acid, uridine, quinolenic acid, citric acid, O-acetylserine, stearic acid, isocitric acid, chondroitinic acid, phenylacetic acid, alanine, 3-phosphoglycerol, arginine, 6- Glucose phosphate, 2hydrouracil, 2-hydroxybutyric acid, hydroxylamine, 2-hydroxyglycolic acid, and 27 biomarkers and pathways related to the TCA cycle, glycerol catabolism, and fatty acid catabolism.
张冉冉, 张艳, 杨秀东. 龙胆泻肝汤治疗慢性氧化性肝损伤的代谢组学机制[J]. 吉林化工学院学报, 2025, 42(3): 12-16.
Zhang Ranran, Zhang Yan, Yang Xiudong . Metabolomic Mechanism of Longdan Xiegan Decoction in the Treatment of Chronic Oxidative Liver Injury. Journal of Jilin Institute of Chemical Technology, 2025, 42(3): 12-16.
