基于静电纺丝法构建用于药物可控释放的醋酸羟丙甲基纤维素琥珀酸酯纳米材料的研究

doi:10.16039/j.cnki.cn22-1249.2020.03.002

摘要
相关文章
推荐阅读
Metrics

下载:

PDF (17242KB)
输出: BibTeX | EndNote (RIS)

摘要

醋酸羟丙甲基纤维素琥珀酸酯（HPMCAS）作为一种典型的肠溶材料在药物可控释放领域具有极大潜力。采用静电纺丝法制备HPMCAS微纳米纤维并对其纺丝参数进行优化。通过研究溶液浓度、纺丝电压、纺丝距离及混合溶剂配比的影响行为，确定制备HPMCAS纳米纤维的最佳工艺参数。通过正交实验及单因素变量设计获得最佳实验条件为：溶液浓度12wt%，电场强度20kV，纺丝距离20cm，溶剂比例CH3OH∶DCM=4∶6。该条件下获得的纤维形貌良好、分布均匀，平均直径为363nm。将为HPMCAS纳米纤维作为智能pH控制药物缓释/控释材料提供理论和实验基础。

	服务
	把本文推荐给朋友
	加入引用管理器
	E-mail Alert
	RSS
	（）
	作者相关文章
	刘梦竹
	郝学艳
	孙伟
	陶俊逸
	王永鹏

关键词: 静电纺丝醋酸羟丙甲基纤维素琥珀酸酯（HPMCAS）微纳米纤维优化

Abstract:

As a typical pH sensitive polymer with biocompatibility, hydroxypropyl methylcellulose acetate succinate (HPMCAS) is a promising material for application in controlled drug release. In this paper, HPMCAS micro-nanofibers were prepared through electrospinning. The optimum condition was obtained by researching the effective of the parameters such as solution concentration, applied voltage, distance and ratio of mixed solvent on fiber morphology and diameter. Through an orthogonal and a single factor experiment, the optimum parameters were determined as a polymer concentration of 12 wt %, a voltage of 20 kV, a collector distance of 20 cm and a solvent ratio (CH3OH/DCM) of 4/6. As a result, the average diameter of fibers is 363m and with good uniformity and smooth morphology. The results will provide theoretical and experimental basis for using HPMCAS nanofibers as intelligent ph-controlled drug sustained-release/controlled-release materials.

Key words: electrospinning hydroxypropyl methylcellulose acetate succinate (HPMCAS) micro-nanofibers optimization

出版日期: 2020-03-25 发布日期: 2020-03-25 整期出版日期: 2020-03-25

ZTFLH:

069

引用本文:

刘梦竹, 郝学艳, 孙伟, 陶俊逸, 王永鹏. 基于静电纺丝法构建用于药物可控释放的醋酸羟丙甲基纤维素琥珀酸酯纳米材料的研究 [J]. 吉林化工学院学报, 2020, 37(3): 6-14.
LIU Mengzhu, HAO Xueyan, SUN Wei, TAO Junyi, WANG Yongpeng. Optimization of Electrospinning Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS) Micro-Nanofibers for Drug Controlled Release . Journal of Jilin Institute of Chemical Technology, 2020, 37(3): 6-14.

链接本文:

http://xuebao.jlict.edu.cn/CN/10.16039/j.cnki.cn22-1249.2020.03.002 或 http://xuebao.jlict.edu.cn/CN/Y2020/V37/I3/6

[1]	郑典亮, 孙婉婷, 周莉, 宇迪. QY200型液压支架立柱优化设计分析 [J]. 吉林化工学院学报, 2020, 37(3): 85-90.
[2]	宋桂阳, 甘新基, 王志豪. 基于热力学分析的FDM3D彩色打印喷头结构优化 [J]. 吉林化工学院学报, 2020, 37(3): 63-66.
[3]	付净, 闫广平, 刘虹, 刘辉, 王泽恒, 胡文强, 程慧慧, 鲁双伟. 工程教育专业认证背景下实践教学现状及优化策略探析——以安全工程专业为例 [J]. 吉林化工学院学报, 2020, 37(2): 23-28.
[4]	赵聚乐, 韩光信. 基于粒子群优化的板球系统双闭环滑模控制 [J]. 吉林化工学院学报, 2020, 37(1): 63-68.
[5]	戴鹂莹, 雷永平, 王晓林, 邸松, 钟方丽. 不同辅助方法对刺玫果总多酚提取率的影响 [J]. 吉林化工学院学报, 2020, 37(1): 20-24.
[6]	钱有程. 改进的无监督同时正交基聚类特征选择 [J]. 吉林化工学院学报, 2019, 36(7): 80-85.
[7]	李婷婷, 薛天福, 宋长虹, 杨梅. 优化补料同步糖化发酵玉米穰产燃料乙醇的研究 [J]. 吉林化工学院学报, 2019, 36(7): 72-75.
[8]	赵会娟, 尹小定. MOLDFLOW在优化空调外壳支架注射成型工艺中的应用 [J]. 吉林化工学院学报, 2019, 36(7): 24-29.
[9]	池恒. 面向三维数字工厂的智能操作优化系统框架设计 [J]. 吉林化工学院学报, 2019, 36(5): 30-34.
[10]	王红, 白鹭, 邹继颖. 环境监测实验课程教学改革研究 [J]. 吉林化工学院学报, 2019, 36(4): 18-20.
[11]	周莉. 基于大工程观的《航空工程材料》课程改革研究与探索 [J]. 吉林化工学院学报, 2019, 36(12): 63-66.
[12]	赵鹤鹏, 刘佳南. 响应面法优化微波辅助提取沙棘籽油的工艺研究 [J]. 吉林化工学院学报, 2019, 36(11): 17-21.
[13]	王宗勇, 赵轶, 何苗, 杨慧茹, 李萍, 薛晓丽. 超临界CO₂流体萃取木耳菌糠最佳工艺的研究 [J]. 吉林化工学院学报, 2019, 36(1): 5-10.
[14]	王继魁. 利用猫群优化算法增强Web服务发现的研究 [J]. 吉林化工学院学报, 2018, 35(11): 46-48.

[1]	. [J]. Journal of Jilin Institute of Chemical Technology, 2018, 35(9): 0 .
[2]	YANG Xian-wei, ZHAN Xue-qiu, KANG Hong-juan, LUO Ying. A Method of Analyzing Image Abnormality by Quadratic Sieve [J]. Journal of Jilin Institute of Chemical Technology, 2018, 35(9): 70 -75 .
[3]	WEI Bai-guang, LV Qiu-yue. Synthesis and Characterization of Sm and Pr Double Mixed CeO₂ based Solid Electrolyte [J]. Journal of Jilin Institute of Chemical Technology, 2018, 35(9): 107 -110 .
[4]	CHEN Chen, LI Hao-ran, WEI Li-zhi, QIAO Hou-dong, ZHANG Yong-wen. The Design and Research of Dynamoelectric Rotary Paper Classifying and Bookbinding Machine [J]. Journal of Jilin Institute of Chemical Technology, 2018, 35(9): 61 -65 .
[5]	. [J]. Journal of Jilin Institute of Chemical Technology, 2018, 35(10): 0 .
[6]	JIN Cheng-zhe, LIU Shu-min. Exploration of the Development of Ice & Snow Sports Industry in Jilin Province in the New Era [J]. Journal of Jilin Institute of Chemical Technology, 2018, 35(10): 1 -5 .
[7]	LIU Gang, HAN Li-zhu. Research on Development of Intellectual Property Integration of Ha-Chang Urban Agglomeration from the Perspective of Strategic Alliances [J]. Journal of Jilin Institute of Chemical Technology, 2018, 35(10): 6 -11 .
[8]	KANG Cui-yu. Research on Early Warning of Financial Risk and Prevention and Control Strategy of P2P Supply Chain [J]. Journal of Jilin Institute of Chemical Technology, 2018, 35(10): 12 -15 .
[9]	LI Gui-juan, ZHAO Wan-yi. Analysis of the Current Situation of Contemporary Youth' Cultural Confidence and Its Construction Path [J]. Journal of Jilin Institute of Chemical Technology, 2018, 35(10): 16 -19 .
[10]	CHE Fei-fei. The Japanization of South Korea Buddhism in Japanese Colonial Era [J]. Journal of Jilin Institute of Chemical Technology, 2018, 35(10): 20 -23 .

Viewed

Full text

Abstract

Cited

Shared

Discussed