白藜芦醇抗肿瘤作用机制的研究现状

doi:10.16039/j.cnki.cn22-1249.2019.05.003

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摘要

白藜芦醇是一种天然多酚类化合物，存在于葡萄、花生等多种植物中，是预防肿瘤的绿色抗癌药物。白藜芦醇可通过抗氧化、调节细胞的氧化还原代谢、干扰细胞自噬和降低细胞的侵袭力等途径发挥抗肿瘤作用。近年来，白藜芦醇在抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡及抑制血管生成等方面越来越受到临床关注，其不仅可以通过胞内胞外途径和周期阻滞诱导肿瘤细胞凋亡，还可以通过调节细胞体内相关信号靶点来抑制肿瘤的迁移。本文就白藜芦醇抗肿瘤作用机制的研究进展进行综述。

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	于明
	张元新

关键词: 白藜芦醇机制癌症

Abstract:

Resveratrol is a kind of natural polyphenol compound with a high content in grapes, peanuts and other plants, and it has been demostrated to be a green anti- cancer drug. Resveratrol may inhibit tumor cells by anti- peroxidation, regulating redox metabolism of cells, interfering with autophagy and reducing cell invasiveness. In recent years, the effects of resveratrol on suppressing the proliferation, inducing the apoptosis and inhibiting angiogenesis of tumor cells have prompted a large interest from researchers, Resveratrol can not only induce the apoptosis of tumor cells via intrinsic or extrinsic pathways and cell cycle arrest, but also inhibit the migration of tumors via modulating collagen degradation related signal target. This paper reviews the research progress of the anti-tutor effect of resveratrol.

Key words: resveratrol mechanism cancer

出版日期: 2019-05-25 发布日期: 2019-05-25 整期出版日期: 2019-05-25

ZTFLH:

R285

引用本文:

于明, 张元新. 白藜芦醇抗肿瘤作用机制的研究现状 [J]. 吉林化工学院学报, 2019, 36(5): 12-15.
YU Ming, ZHANG Yuanxin. Research Stotus of the Anti-tumor Mechanism of Resveratrol. Journal of Jilin Institute of Chemical Technology, 2019, 36(5): 12-15.

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http://xuebao.jlict.edu.cn/CN/10.16039/j.cnki.cn22-1249.2019.05.003 或 http://xuebao.jlict.edu.cn/CN/Y2019/V36/I5/12

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