In view of the problems existing in the traditional Organic Chemistry classroom teaching, combined with the "Internet +" information science and technology, the reform and practice of diversified online and offline mixed teaching mode was carried out based on the Super-Star learning platform. This paper explores the application of multiple teaching mode in Organic Chemistry classroom teaching from three main learning stages: before class, during class and after class. After preliminary exploration, the implementation of multiple teaching mode has achieved good teaching effect, which helps students to actively participate in the organic chemistry class, cultivate their logical thinking ability, and improve their ability to apply knowledge to scientific research under the background of new engineering.