According to the progressive process of the transformation from knowledge to ability in computational thinking theory, a multi-mixed teaching mode based on hierarchical cognitive model is constructed. Taking college computer course as an example, students' autonomous learning and cooperative learning is encouraged, high-quality teaching resources is developed and integrated and diversified teaching activities is designed for the purpose of cultivating students' comprehensive application of computer software and hardware knowledge to solve the practical problems of the major, and finally it is used to the "SPOC + flipped classroom" mixed teaching to achieve the teaching goal.